Imidazole → 1-(2-fluoro-4-nitrophenyl)-1H-imidazole

Participants

Role	Name	HCID	Charge
Reactant	Imidazole	HCID 795	—
Reactant	Water	HCID 962	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1,2-Difluoro-4-nitrobenzene	HCID 123053	—
Solvent	Dimethylformamide	HCID 6228	—
Product	1-(2-fluoro-4-nitrophenyl)-1H-imidazole	HCID 5306153	96.8%

Reaction Steps

A mixture of 3,4-difluoronitrobenzene (1.00 mL, 9.03 mmol), imidazole (0.615 g, 9.04 mmol) and K2CO3 (2.50 g, 18.1 mmol) in DMF (10 mL) was stirred at room temperature overnight. Water (20 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give 1-(2-fluoro-4-nitrophenyl)-1H-imidazole as a solid (1.81 g). MS 208.2 (M+H)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08318755B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-96dd082517804f0dbe71b43acf9b75c0
Source note	uspto-grants-2012_11