Ethanol → HCID 178492734, compound

Participants

Reaction Steps

To a solution of ethyl 7-methoxy-3-methyl-1H-indazole-5-carboxylate (516 mg, 2.08 mmol) in THF (17 mL) was added 1 M LiOH (4.2 mL, 4.2 mmol) and the mixture was heated at reflux overnight. Analysis indicated the presence of small amounts of unreacted starting material; therefore, a small amount of ethanol was added to assist in solubilizing materials. Heating was continued for an additional 2 hours before concentrating to dryness. The residue was triturated with 1 N HCl, the solids were isolated by filtration, washed with water and air dried overnight to provide the title compound as an off-white solid (417 mg, 91%).

Provenance & Evidence