Lithium Hydroxide → HCID 178438019, compound

Participants

Reaction Steps

To a solution of 3-ethyl-7-methoxy-1H-indazole-5-carboxylate (1.05 g, 4.23 mmol) in THF (35 mL) was added 1 M LiOH (8.46 mL, 8.46 mmol) and the mixture was heated at reflux overnight. The mixture was concentrated and the residue was triturated with 1 N HCl. The precipitates were washed with water and air dried. The solids were then taken up in hot methanol, filtered, concentrated and dried overnight under high vacuum to provide the title compound as an off-white solid (849 mg, 91%).

Provenance & Evidence