Hydrazine hydrate (1:1) → HCID 178434225, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(5-bromo-2-fluoro-phenyl)-ethanone (10 g, 46 mmol) in hydrazine hydrate (80 mL) was heated at reflux (130° C.) for 20 hours. The reaction mixture was cooled to room temperature, excess hydrazine hydrate was removed and the crude residue was purified by column chromatography (60-120 mesh silica gel) using 10% ethyl acetate in pet-ether as eluents to obtain 5-bromo-3-methyl-1H-indazole (7.09 g, 73%) as a solid. 1H NMR (CDCl3): δ 10.2-10.6 (br, 1H), 7.8-7.9 (s, 1H), 7.4-7.5 (d, 1H), 7.2-7.4 (d, 1H), 2.5-2.7 (s, 3H).

Provenance & Evidence