Ethanol → HCID 178466834, compound

Participants

Reaction Steps

To a solution of ethyl 7-ethoxy-3-ethyl-1H-indazole-5-carboxylate (389 mg, 1.48 mmol) in THF (13 mL) was added 1 M LiOH (3.0 mL, 3.0 mmol). The mixture was heated at reflux overnight. To the reaction was added trace amounts of ethanol to aid in solubilizing materials. Continue heating at reflux for an additional 2 hours. The reaction was cooled to room temperature, concentrated, triturated with 1 N HCl, the filtered solids were then washed with water and air dried to provide the title compound (347 mg, 97%).

Provenance & Evidence