Water → HCID 178487565, compound

Participants

Reaction Steps

A solution of 2-fluoro-4-methoxyactophenone (2.0 g, 12 mmol) in hydrazine hydrate (30 mL) was heated at reflux for two days. The mixture was cooled to room temperature, poured into water and extracted with EtOAc (3×). The organic extracts were concentrated, dissolved in a minimal amount of CH2Cl2 and filtered to afford 6-methoxy-3-methyl-1H-indazole (370 mg, 19%). The filtrate was refiltered to provide additional product (250 mg, 13%).

Provenance & Evidence