Stannous Chloride → HCID 178438015, compound

Participants

Reaction Steps

1-(2-Amino-5-bromo-3-chloro-phenyl)-propan-1-one (130.0 mg, 0.50 mmol) dissolved in aqueous 50% H2SO4 (2.5 mL) and NaNO2 (43.1 mg, 0.59 mmol) was slowly added to this mixture at 0° C. The mixture was then stirred at room temperature for 1 hour. SnCl2 2H2O (342.0 mg, 1.48 mmol) was then added, and the mixture was stirred at 0° C. for 1 hour, and then diluted with water. White solid appeared and was collected by filtration and dried to afford 5-bromo-7-chloro-3-ethyl-1H-indazole as a solid (127.0 mg, 98.8%).

Provenance & Evidence