反应详情

To a solution of 7-ethyl-1H-indazole-5-carboxylic acid (500 mg, 2.63 mmol) in MeOH (15 mL) was added conc. H2SO4 (0.25 mL). The mixture was heated at reflux overnight. The solvent was removed under reduced pressure to afford a tan solid that was purified by flash chromatography (40 g column) using 15-30% EtOAc/heptane to afford methyl 7-ethyl-1H-indazole-5-carboxylate (252 mg, 47%).

1. temperatureThe mixture was heated
2. temperatureat reflux overnight
3. customThe solvent was removed under reduced pressure
4. customto afford a tan solid
5. customthat was purified by flash chromatography (40 g column)