Hexane → HCID 66920555, compound

Participants

Reaction Steps

To stirred triethyl orthoacetate (35.0 mL, 190 mmol), 3-amino-4,5-dihydroxybenzoate hydrochloride (6.00 g, 27.3 mmol) was added. The stirred suspension was refluxed for 20 minutes and cooled to room temperature. The reaction mixture was poured into hexane (200 mL). The formed precipitate was separated by filtration and vacuum-dried to afford benzoxazole methyl 7-hydroxy-2-methyl-1,3-benzoxazole-5-carboxylate (4.98 g, 24.04 mmol, 88% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.74 (br. s, 1H), 7.66 (d, J=1.4 Hz, 1H), 7.43 (d, J=1.4 Hz, 1H), 3.85 (s, 3H), 2.62 (s, 3H).

Provenance & Evidence