HCID 11713695, compound → HCID 11583416, compound

HRID 1880468Notes

Reaction equation

HRID 1880468 reaction equation
C([O:8][C:9]1[CH:41]=[CH:40][C:12]2[C:13]3[N:14]([CH2:25][C:26]4[CH:39]=[CH:38][C:29]([O:30][CH2:31][CH2:32][N:33]([CH2:36][CH3:37])[CH2:34][CH3:35])=[CH:28][CH:27]=4)[C:15]4[CH:16]=[CH:17][C:18]([O:23][CH3:24])=[CH:19][C:20]=4[C:21]=3[O:22][C:11]=2[CH:10]=1)C1C=CC=CC=1>CCO.[Pd]>[CH2:36]([N:33]([CH2:34][CH3:35])[CH2:32][CH2:31][O:30][C:29]1[CH:38]=[CH:39][C:26]([CH2:25][N:14]2[C:15]3[CH:16]=[CH:17][C:18]([O:23][CH3:24])=[CH:19][C:20]=3[C:21]3[O:22][C:11]4[CH:10]=[C:9]([OH:8])[CH:41]=[CH:40][C:12]=4[C:13]2=3)=[CH:27][CH:28]=1)[CH3:37]

Participants

4

Reactant 1

HCID 11713695HCID 11713695, compound

Product 1

HCID 11583416HCID 11583416, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of {2-[4-(7-benzyloxy-3-methoxy-benzo[4,5]furo[3,2-b]indol-10-ylmethyl)-phenoxy]-ethyl}-diethyl-amine (102 mg, 0.186 mmol) and 10% Pd/C (˜100 mg) in EtOH (10 mL) was stirred under a H2 balloon at 25° C. overnight. The solution was filtered, concentrated and purified to yield the title compound as a yellow solid.

Workup

  1. filtrationThe solution was filtered
  2. concentrationconcentrated
  3. custompurified

Sources & evidence

ORD record
ord-581f3e09864d4d5e8e99b8b72a603eed
Source dataset
uspto-grants-2012_11
Patent number
US08318766B2

Reaction notes

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