HCID 59676079, compound → HCID 59676073, compound

HRID 1880471Notes

Reaction equation

HRID 1880471 reaction equation
[C:1]([Si:5]([CH3:26])([CH3:25])[O:6][C:7]1[CH:8]=[CH:9][C:10]2[NH:19][C:18]3[C:17]4[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=4[S:15][CH2:14][CH2:13][C:12]=3[C:11]=2[CH:24]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl[CH2:29][C:30]1[CH:45]=[CH:44][C:33]([O:34][CH2:35][CH2:36][NH:37][CH:38]2C[CH2:42][CH2:41][CH2:40][CH2:39]2)=[CH:32][CH:31]=1>>[C:1]([Si:5]([CH3:26])([CH3:25])[O:6][C:7]1[CH:8]=[CH:9][C:10]2[N:19]([CH2:29][C:30]3[CH:31]=[CH:32][C:33]([O:34][CH2:35][CH2:36][N:37]4[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]4)=[CH:44][CH:45]=3)[C:18]3[C:17]4[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=4[S:15][CH2:14][CH2:13][C:12]=3[C:11]=2[CH:24]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 59676079HCID 59676079, compoundHCID 67237209HCID 67237209, compound

Product 1

HCID 59676073HCID 59676073, compound

Procedure

Following the same procedure in Example 102, using 9-(tert-Butyl-dimethyl-silanyloxy)-6,7-dihydro-12H-5-thia-12-aza-dibenzo[a,e]azulene (190 mg, 0.5 mmol) and [2-(4-chloromethyl-phenoxy)-ethyl]-cyclohexanyl-amine hydrochloride salt as the starting material, title compound was prepared as a brown solid. The compound was used in the next step without additional purification.

Sources & evidence

ORD record
ord-d7a95836fd0f4fd0bf809da010070280
Source dataset
uspto-grants-2012_11
Patent number
US08318766B2

Reaction notes

Loading…