HCID 10287617, compound → HCID 59715491, compound

HRID 1880496Notes

Reaction equation

HRID 1880496 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:13][C@H:14]([C:19]([NH:21][CH2:22][C:23]#[N:24])=[O:20])[CH2:15][CH:16]([CH3:18])[CH3:17])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.BrC1C=C(C(N[C@H:38]([C:43]([NH:45][CH2:46][C:47]#N)=O)[CH2:39]C(C)C)C(F)(F)F)C=CC=1>>[C:23]([CH2:22][NH:21][C:19](=[O:20])[C@H:14]([CH2:15][CH:16]([CH3:18])[CH3:17])[NH:13][CH:8]([C:5]1[CH:6]=[CH:7][CH:2]=[C:3]([C:39]2[CH:38]=[CH:43][N:45]=[CH:46][CH:47]=2)[CH:4]=1)[C:9]([F:12])([F:11])[F:10])#[N:24]

Participants

3

Reactant 2

HCID 10287617HCID 10287617, compoundHCID 86590540HCID 86590540, compound

Product 1

HCID 59715491HCID 59715491, compound

Procedure

Using the procedure described for example 8, where N2-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N1-(cyanomethyl)-L-leucinamide was substituted for N2-[1-(3-bromophenyl)-2,2,2-trifluoroethyl]-N1-(cyanomethyl)-L-leucinamide, the title compound was obtained as a colorless gum.

Sources & evidence

ORD record
ord-5b8fcc8059814b7a9a5854edcbcde18f
Source dataset
uspto-grants-2012_11
Patent number
US08318748B2

Reaction notes

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