HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 178445929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2,2,2-Trifluoro-1-methoxyethanol | HCID 9892 | — |
| Reactant | {[(2S)-2-amino-4-methylpentyl]oxy}(tert-butyl)dimethylsilane | HCID 11345273 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178445929 | HCID 178445929 | — |
Reaction Steps
A toluene (300 mL) solution of (2S)-1-{[tert-butyl(dimethyl)silyl]oxy}-4-methylpentan-2-amine from Step 1 (50 g) and trifluoroacetaldehyde methyl hemiacetal (35 mL) was heated to reflux for 16 hours during which time water was collected in a Dean-Stark trap. The solvent was evaporated in vacuum and the residue was purified on SiO2 using hexanes and ethyl acetate (9:1) as eluant to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318748B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-d546371a68444ffb8b77041dc923690d |
| Source note | uspto-grants-2012_11 |