HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzaldehyde → (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | L-Leucinol | HCID 111307 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol | HCID 57515778 | — |
Reaction Steps
A mixture of (L)-leucinol (1.13 g, 9.67 mmol) and 4-fluorobenzaldehyde (1.20 g, 9.67 mmol) was dissolved in benzene (30 mL) and heated at reflux for 1 hour, using a Dean-Stark apparatus to remove water. (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol was isolated by concentration in vacuo, and was used immediately without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318748B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-cd780985c64d4e8f8348c8d7039047a9 |
| Source note | uspto-grants-2012_11 |