Water → HCID 57446953, compound

HRID 1880537Notes

Reaction equation

HRID 1880537 reaction equation
[NH2:1][C@H:2]([CH2:7][OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[F:9][C:10]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:11]=1[CH:12]=O.O>C1C=CC=CC=1>[F:9][C:10]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:11]=1[CH:12]=[N:1][C@@H:2]([CH2:3][CH:4]([CH3:6])[CH3:5])[CH2:7][OH:8]

Participants

5

Reactant 3

HCID 962WaterHCID 737702,4-DifluorobenzaldehydeHCID 111307L-Leucinol

Product 1

HCID 57446953HCID 57446953, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of (S)-(+)-leucinol (2.47 g, 21 mmol) and 2,4-difluorobenzaldehyde (3 g, 21 mmol) in benzene (50 mL) was heated to reflux for 4 hours during which time water was collected in a Dean-Stark trap. The solvent was evaporated in vacuum to give (2S)-2-[(2,4-difluorobenzylidene)-amino]-4-methylpentan-1-ol.

Workup

  1. customwas collected in a Dean-Stark trap
  2. customThe solvent was evaporated in vacuum

Sources & evidence

ORD record
ord-5b945214c3b24ea8a6c3488f03342384
Source dataset
uspto-grants-2012_11
Patent number
US08318748B2

Reaction notes

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