HRID1880561

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734364

4-(Methylsulfonyl)phenylboronic acid

C7H9BO4S

结构：CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)c1nccs1)C(=O)NC1(C#N)CC1

HCID59715509

未命名化合物

结构：CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)c1nccs1)C(=O)NC1(C#N)CC1

HCID67298346

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)c1nccs1)C(=O)NC1(C#N)CC1

HCID67298719

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1

催化剂HCID178418228

Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)

C34H28Cl2FeP2Pd

PROCEDURE

实验过程

The title compound was prepared in similar manner to that described for (2S)-2-{(S)-[(2′,4′-difluorobiphenyl-4-yl)-thiazol-2-yl-methyl]-amino}-4-methylpentanoic acid (1-cyanocyclopropyl)-amide, via Suzuki cross-coupling of (2S)-2-{(S)-[(4-bromophenyl)-thiazol-2-yl-methyl]-amino}-4-methylpentanoic acid (1-cyanocyclopropyl)-amide with 4-methanesulfonylphenylboronic acid, in the presence of [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II), dichloromethane complex.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-502c6bc26f1b419c9ab699695a728ed1
来源数据集: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08318748B2
来源说明: uspto-grants-2012_11

反应 SMILES

[C:1]([C:3]1([NH:6][C:7](=[O:34])[C@@H:8]([NH:13][C@@H:14]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29](F)=[CH:28][C:27]=3F)=[CH:22][CH:21]=2)[C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[CH2:9][CH:10]([CH3:12])[CH3:11])[CH2:5][CH2:4]1)#[N:2].C(C1(NC(=O)[C@@H](N[C@@H](C2C=CC(Br)=CC=2)C2SC=CN=2)CC(C)C)CC1)#N.[CH3:62][S:63](C1C=CC(B(O)O)=CC=1)(=[O:65])=[O:64]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[C:1]([C:3]1([NH:6][C:7](=[O:34])[C@@H:8]([NH:13][C@@H:14]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([S:63]([CH3:62])(=[O:65])=[O:64])=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)[C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[CH2:9][CH:10]([CH3:12])[CH3:11])[CH2:5][CH2:4]1)#[N:2]