Lithium Hydroxide → HCID 69308244, compound

Participants

Reaction Conditions

Reaction Steps

To a THF/MeOH/water solution (ca. 40 mL/40 mL/10 mL) of the intermediate from Step F (8.53 g, 17.84 mmol) was added LiOH (3.66 g, 89.2 mmol). The solution was stirred at 45° C. until no starting material remained by HPLC (ca. 2 hrs). The solution was concentrated to remove the majority of MeOH/THF and then partitioned between aqueous 1N HCl and ethyl acetate. The organic phase was washed with water (2×), brine and dried over Na2SO4. The solution was filtered and concentrated to give the title compound. The crude material was use in the next step without purification.

Provenance & Evidence