Cesium carbonate → HCID 59756932, compound

Participants

Reaction Conditions

Reaction Steps

A toluene (3 mL) solution containing 1,3-dichloroisoquinoline (50 mg, 0.25 mmol), 4-(hydroxymethyl)benzoate (105 mg, 0.63 mmol), cesium carbonate (206 mg, 0.63 mmol), palladium acetate (5 mg, 0.02 mmol) and racemic-2-(di-t-butylphosphino)-1,1′-binaphthyl (14 mg, 0.035 mmol) was heated at 75° C. for 1.5 hours. The solution was partitioned between ethyl acetate and water. The organic phase was washed with brine and dried over MgSO4. The solution was filtered, concentrated and the residue purified by silica gel chromatography using hexanes/ethyl acetate gradient. 1H NMR (500 MHz, CDCl3): δ 8.30 (d, J=8.3 Hz, 1H); 8.13 (d, J=8.3 Hz, 2H); 7.72-7.70 (m, 2H); 7.65 (d, J=8.2 Hz, 2H); 7.59-7.55 (m, 1H); 7.34 (s, 1H); 5.68 (s, 2H); 3.98 (s, 3H). LCMS2 2.73 min. (M+H)=328

Provenance & Evidence