1,3-Dichloroisoquinoline → HCID 59756919, compound

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Reaction Steps

The title compound was prepared from 1,3-dichloroisoquinoline and racemic methyl 4-(1-hydroxyethyl)benzoate as described in the preparation of INTERMEDIATE 3. 1H NMR (500 MHz, CDCl3): δ 8.35 (d, J=8.4 Hz, 1H); 8.08 (d, J=8.3 Hz, 2H); 7.72-7.68 (m, 2H); 7.64 (d, J=8.3 Hz, 2H); 7.60-7.56 (m, 1H); 7.31 (s, 1H); 6.56 (q, J=6.6 Hz, 1H); 3.95 (s, 3H); 1.81 (d, J=6.5 Hz, 3H). LCMS1 4.26 min. (M-(CH3CHPhCO2Me)+H)=180

Provenance & Evidence