HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1880598Generated: October 31, 2026
Diisopropylethylamine → HCID 178522665, compound
https://huagongshe.com/reaction/1880598
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 69311697 | HCID 69311697 | — |
| Reactant | HCID 178509299 | HCID 178509299 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178522665 | HCID 178522665 | — |
Reaction Steps
A DMF solution (1 mL) containing 4-{2-[3-chloro-4″-(trifluoromethoxy)-1,1′:4′,1″-terphenyl-2′-yl]ethyl}benzoic acid (12 mg, 0.024 mmol), prepared using the procedures described in EXAMPLE 1, DIEA (21 μg, 0.12 mmol), 1H-tetrazol-5-amine (3 mg, 0.036 mmol), and BOP (21 mg, 0.048 mmol) was heated at 50° C. for 30 minutes. The solution was then purified directly by RP-HPLC to give the title compound. LCMS1 4.36 min (N+H)=564
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08318760B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-853b141655194931a3e610b567703e95 |
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| Source note | uspto-grants-2012_11 |
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