Methyl 5-amino-2-bromobenzoate → N-[4-({7-[4-(TRIFLUOROMETHOXY)PHENYL]-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL}METHYL)BENZOYL]-beta-ALANINE

Participants

Reaction Steps

The compounds in TABLE 1 were prepared using the chemistry described in EXAMPLES 1, 4, 5 and 6 or with following modifications: 1) EXAMPLES 47 to 50 (where R1=R21) were prepared as described in EXAMPLE 1 substituting 4-bromo-4′-(trifluoromethoxy)biphenyl-3-carbaldehyde with 2,5-dibromobenzaldehyde; 2) EXAMPLES 117 to 133 were prepared as described in EXAMPLE 1 substituting methyl 2-amino-5-bromobenzoate with methyl 5-amino-2-bromobenzoate; 3) EXAMPLES 111 to 113 were prepared from the intermediate from EXAMPLE 1 Step H using the procedure described in EXAMPLE 42A/42B.

Provenance & Evidence