Sulfuryl chloride → HCID 68510317, compound

HRID 1880604Notes

Reaction equation

HRID 1880604 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][NH:9][CH2:8][CH2:7]2.S(Cl)([Cl:19])(=O)=O>C(O)(=O)C>[ClH:19].[Cl:1][C:5]1[C:4]([O:3][CH3:2])=[C:13]([O:14][CH3:15])[C:12]([Cl:19])=[C:11]2[C:6]=1[CH2:7][CH2:8][NH:9][CH2:10]2

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 64560356,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Product 1

HCID 68510317HCID 68510317, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (200 mg, 0.870 mmol) was suspended in glacial acetic acid (5 mL) and sulphuryl chloride (154 μL, 1.92 mmol) was added slowly. The resulting mixture was stirred at room temperature for 3 hours and then evaporated to give the title compound (quant) as a yellowish mass.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-a661c6dedfb741e2bc34d2f1409ea124
Source dataset
uspto-grants-2012_11
Patent number
US08318768B2

Reaction notes

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