HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline-6,7-diol--hydrogen bromide (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 68510317 | HCID 68510317 | — |
| Product | 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline-6,7-diol--hydrogen bromide (1/1) | HCID 68508172 | — |
Reaction Steps
5,8-Dichloro-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1.0 g, 3.35 mmol) was suspended in aqueous HBr (48%, 10 mL) and refluxed for 5 hours before evaporation. The remaining residue was evaporated twice from toluene to give 1.05 g (quant) of the title compound as a pale solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318768B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-00f51531e9e346a685d5c7b55954a003 |
| Source note | uspto-grants-2012_11 |