Sodium Hydroxide → HCID 68509953, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(6-(trifluoromethyl)pyridin-3-yl)but-2-enoate (2.9 g, 11 mmol) in EtOH/THF 1/1 (34 mL) was added 1M NaOH (aq.) (34 mL). The resulting mixture was heated at 60° C. for 1 h after which the reaction mixture was allowed to cool to rt. The volatiles were evaporated and the remaining water phase neutralized with 1 M HCl(aq.). The title compound (2.4 g, 10 mmol, 91%), which precipitated as a white solid, was filtered off and dried under vacuum at 55° C. over night. This material was used directly in the next step, without further purification.

Provenance & Evidence