Sodium Hydroxide → HCID 57808084, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)-methyl 3-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)acrylate (Gray, M.; Andrews, I. P.; Hook, D. F.; Kitteringham, J.; Voyle, M. Tet. Lett. 2001, 41, 6237-6240.) (150 mg, 0.61 mmol) in MeOH (2.0 mL) was added 1M NaOH (aq.) (1.8 mL). The reaction mixture was stirred for 2 h at 40° C. The volatiles were then evaporated and the remaining water phase neutralized with 1M HCl (aq). The title compound (141 mg, 0.61 mmol, quant.), which precipitated as a white solid, was filtered off and dried under vacuum at 45° C. This material was used directly in the next step without further purification.

Provenance & Evidence