HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N1,N3-dimethyl-N1-(thiazol-2-yl)propane-1,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N,N'-Dimethyl-1,3-propanediamine | HCID 66978 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N1,N3-dimethyl-N1-(thiazol-2-yl)propane-1,3-diamine | HCID 69151207 | 60% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
2.45 g (24.0 mmol) N,N3-dimethylpropane-1,3-diamine was added to 0.36 ml (4.0 mmol) 2-bromothiazole and heated to 120° C. for 1 h. After cooling to RT, dilution with water and chloroform took place. The phases were separated and the aqueous phase was extracted with chloroform. The combined organic phases were dried over MgSO4, filtered, and concentrated in vacuo. Column chromatography (SiO2, DCE/MeOH/25% aq. NH3-soln 4:4:1) was carried out on the residue, yielding 440 mg (2.4 mmol, 59%) N1,N3-dimethyl-N1-(thiazol-2-yl)propane-1,3-diamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318774B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-a6ee07d53c424b61a6ce95f023a0907e |
| Source note | uspto-grants-2012_11 |