2-Bromothiazole → HCID 69235537, compound

Participants

Reaction Steps

A solution of 541 μl (6.0 mmol) 2-bromothiazole and 1.27 g (6.0 mmol) hexahydro-pyrrolo[3,4-c]pyrrol-2-carboxylic acid tert-butyl-ester in n-butanol (10 ml) was heated for 2 h under reflux. Subsequently, the solvent was removed in vacuo and the residue taken up by chloroform. This solution was washed with water and brine in turn, dried over MgSO4, filtered and concentrated in vacuo. Column chromatography was carried out on the residue (SiO2, DCM/EtOH 10:1), yielding 450 mg (1.53 mmol, 25%) 5-thiazol-2-yl-hexahydro-pyrrolo[3,4-c]pyrrol-2-carboxylic acid tert-butyl-ester.

Provenance & Evidence