HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(Thiazol-2-yl)piperidin-4-amine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (1-(thiazol-2-yl)piperidin-4-yl)carbamate | HCID 69231551 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Thiazol-2-yl)piperidin-4-amine trifluoroacetate | HCID 69152873 | 86% |
Reaction Steps
Trifluoroacetic acid (10 ml) was added to a solution of 1.14 g (4.00 mmol) (1-thiazol-2-yl-piperidin-4-yl)-carbamic acid-tert-butyl ester in DCM (10 ml). The reaction solution was stirred for 1 h at RT and subsequently concentrated in vacuo. 1.02 g (0.34 mmol, 86%) 1-(thiazol-2-yl)piperidin-4-amine trifluoroacetate were obtained by crystallisation of the residue from an ethanol/EE-mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318774B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-0f23662a8d41474eb26ea37678df3c50 |
| Source note | uspto-grants-2012_11 |