Dimethylcarbamoyl Chloride → HCID 59570370, compound

Participants

Reaction Steps

To 1 ml of pyridine were added 0.26 g of 1,8-diazabicyclo[5,4,0]undec-7-ene, and 0.3 g of 3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one, and 0.18 g of N,N-dimethylcarbamoyl chloride was added at room temperature. After stirring for 20 hours, the resultant solution was concentrated, and the residue was subjected to silica gel column chromatography to obtain 0.25 g of 3-(4-trifluoromethylpyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazol-5-one-4-carboxamide (present compound (14)).

Provenance & Evidence