Ethanol → 3-[3-(4-Trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-on-4-yl]propionaldehyde

Participants

Reaction Steps

To 1 ml of ethanol were added 0.12 g of triethylamine, 0.2 g of 3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one, and 0.05 g of acrolein, the mixture was stirred at room temperature for 18 hours, and concentrated, and the residue was subjected to silica gel column chromatography to obtain 0.16 g of 3-[3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-on-4-yl]propionaldehyde (present compound (22)).

Provenance & Evidence