Hydrochloric Acid → HCID 178517528, compound

Participants

Reaction Steps

To 2 ml of dimethyl sulfoxide were added 0.3 g of 3-[4-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]-1,2,4-oxadiazol-5-one and 0.48 ml of triethylamine, and 1 ml of a solution of 0.55 g of sulfur-trioxide-pyridine complex in dimethyl sulfoxide was added dropwise. After stirring for 8 hours, 0.17 g of sulfur-trioxide-pyridine complex was added, and the mixture was further stirred for 7 hours. To the reaction solution were added water and 10% HCl, the resultant solution was extracted with ethyl acetate three times, and the organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.18 g of 3-{4-[2,2,2-trifluoro-1,1-dihydroxyethyl]pyridin-2-yl}-1,2,4-oxadiazol-5-one (present compound (58)).

Provenance & Evidence