Hydrochloric Acid → HCID 178466936, compound

Participants

Reaction Steps

To 3 ml of tetrahydrofuran was added 12 g of 3-{4-[2,2,2-trifluoro-1-methyl-1-(trimethylsilyloxy)ethyl]pyridin-2-yl}-1,2,4-oxadiazol-5-one, and 1.3 ml of tetrabutylammonium=fluoride (1M tetrahydrofuran solution) was added at 0° C. After stirring at room temperature for 4 hours, water and 10% HCl were added to the reaction solution, the resultant solution was extracted with ethyl acetate three times, and the organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.29 g of 3-[4-(2,2,2-trifluoro-1-methyl-1-hydroxyethyl)pyridin-2-yl]-1,2,4-oxadiazol-5-one (present compound (62)).

Provenance & Evidence