Acetonitrile → HCID 59570361, compound

Participants

Reaction Conditions

Reaction Steps

To 30 ml of acetonitrile were added 4 g of 4-[2,2,2-trifluoro-1-methyl-1-(trimethylsilyloxy)ethyl]pyridine=N-oxide, 4.45 ml of triethylamine, and 4.75 g of trimethylsilyl cyanide, and the mixture was stirred at 90° C. for 20 hours. Thereafter, the reaction solution was allowed to cool to room temperature, and concentrated. The residue was subjected to silica gel column chromatography to obtain 4.3 g of 4-[2,2,2-trifluoro-1-methyl-1-(trimethylsilyloxy)ethyl]pyridine-2-carbonitrile.

Provenance & Evidence