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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1880771Erstellt: 25. Oktober 2026

4-[1-(Trifluoromethyl)ethenyl]pyridine → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine

https://huagongshe.com/reaction/1880771

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt4-[1-(Trifluoromethyl)ethenyl]pyridineHCID 59570355—
EduktHCID 178418361HCID 178418361—
KatalysatorPalladiumHCID 23938—
LösungsmittelEthyl AcetateHCID 8857—
Produkt4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridineHCID 5957033785,7%

Reaktionsschritte

To 20 ml of ethyl acetate were added 1.5 g of 4-[1-(trifluoromethyl)ethenyl]pyridine and 0.15 g of 10% Pd/C, and the mixture was stirred under the hydrogen atmosphere for 7 hours. The mixture was filtered, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain 1.3 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08318776B2
Quelldatensatzuspto-grants-2012_11
ORD IDord-3931ff0361f24cb786007c5b926220fa
Quellennotizuspto-grants-2012_11