Acetonitrile → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine-2-carbonitrile

Participants

Reaction Conditions

Reaction Steps

To 8 ml of acetonitrile were added 0.9 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine=N-oxide, 1.31 ml of triethylamine and 1.4 g of trimethylsilyl cyanide, and the mixture was stirred at 90° C. for 16 hours. Thereafter, the reaction solution was allowed to cool to temperature, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.7 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine-2-carbonitrile.

Provenance & Evidence