HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate | HCID 23078240 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride | HCID 66798194 | — |
Reaction Steps
146 g of tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate (0.414 mol) are dissolved in 2 L of dichloromethane. 190 mL of trifluoroacetic acid are added dropwise. The reaction mixture is stirred at room temperature for twelve hours, concentrated to dryness and diluted in 300 mL of hydrochloric acid 2M.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318777B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-3321531559074af4b1ba5ee3022a6065 |
| Source note | uspto-grants-2012_11 |