Sodium Chloride → HCID 63199034, compound

HRID 1880782Notes

Reaction equation

HRID 1880782 reaction equation
[Cl:1][C:2]1[C:3]([CH:12]([C:17](=[O:20])[CH2:18][CH3:19])C(OC)=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl-].[Na+]>O.CS(C)=O>[Cl:1][C:2]1[C:3]([CH2:12][C:17](=[O:20])[CH2:18][CH3:19])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

5

Reactant 2

HCID 5234Sodium ChlorideHCID 23078246HCID 23078246, compound

Product 1

HCID 63199034HCID 63199034, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent2×

Conditions

Temperature
130 °C

Procedure

2.08 g of methyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-3-oxopentanoate (0.00677 mol) and 0.12 g of sodium chloride are dissolved in a mixture of water (0.25 mL) and dimethylsulfoxyde (20 mL). The reaction medium is stirred at a temperature of 130° C. for 8 hours. After cooling, 100 mL of water are added to the reaction mixture which is extracted twice with 150 mL of ethyl acetate.

Workup

  1. temperatureAfter cooling
  2. extractionis extracted twice with 150 mL of ethyl acetate

Sources & evidence

ORD record
ord-9e060129157f4be8aaa365a84ee39405
Source dataset
uspto-grants-2012_11
Patent number
US08318777B2

Reaction notes

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