Propylamine → HCID 25252906, compound

Participants

Reaction Steps

The title compound was synthesized from 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-propylamine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.57 (dd, J=3.66, 2.40 Hz, 2 H) 0.70 (dd, J=6.95, 2.15 Hz, 2 H) 1.50-1.77 (m, 6 H) 1.88-1.97 (m, 2 H) 2.82 (td, J=7.33, 3.54 Hz, 1 H) 3.17 (s, 3 H) 3.92 (s, 3 H) 3.99-4.08 (m, 3 H) 4.75 (d, J=8.84 Hz, 1 H) 7.40-7.51 (m, 2 H) 7.96 (s, 1 H) 8.26 (d, J=8.34 Hz, 1 H) 8.35 (d, J=4.04 Hz, 1 H). [M+H] C24H28F2N6O3 calc'd for, 487; found 487.

Provenance & Evidence