2-(Dimethylamino)acetyl chloride → 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-3-methoxybenzamide

Participants

Reaction Steps

The title compound was synthesized from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(piperidin-4-yl)benzamide in accordance with scheme 6 using 2-(dimethylamino)acetyl chloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.38 (dd, J=13.1, 4.0 Hz, 1 H) 1.58 (m, 5 H) 1.71 (m, 2 H) 1.83 (m, 2 H) 1.93 (m, 2 H) 2.21 (s, 5 H) 2.52 (d, J=1.8 Hz, 1 H) 2.63-2.73 (m, 1 H) 3.05 (t, J=12.1 Hz, 2 H) 3.17-3.24 (m, 1 H) 3.32 (s, 5 H) 3.93 (s, 3 H) 4.05 (t, J=14.2 Hz, 3 H) 4.36 (d, J=12.6 Hz, 1 H) 4.77 (q, J=8.3 Hz, 1 H) 7.48 (dd, 1 H) 7.50 (s, 1 H) 7.97 (s, 1 H) 8.17 (d, J=7.8 Hz, 1 H) 8.26 (s, 1 H) 8.29 (d, 1H). [M+H] calc'd for C30H40F2N8O4, 615; found 615.

Provenance & Evidence