HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidinamine → HCID 25253220, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidinamine | HCID 27946 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid | HCID 25252905 | — |
| Product | HCID 25253220 | HCID 25253220 | — |
Reaction Steps
The title compound was synthesized from 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and pyrrolidin-1-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.43-1.75 (m, 6 H) 1.90-2.02 (m, 2 H) 2.67-3.03 (m, 4 H) 3.57 (s, 3 H) 3.95 (s, 3 H) 4.05 (t, 2 H) 4.73-4.81 (m, 1 H) 7.48-7.54 (m, 2 H) 8.00 (s, 1 H) 8.20 (d, 1 H) 8.27 (s, 1 H) 8.30 (d, 1 H). [M+H] calc'd for C25H31F2N7O3, 516; found 516.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318727B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-9f5e054f72ec4a10ba358ba3f8c78260 |
| Source note | uspto-grants-2012_11 |