6-Amino-1,3-dihydro-2H-indol-2-one → HCID 25253371, compound

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Reaction Steps

The title compound was synthesized using an analogous procedure to that described in connection with 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid from 2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one and 6-aminoindolin-2-one. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.45-1.86 (m, 6 H) 1.92-2.16 (m, 2 H) 3.39 (s, 3 H) 3.54 (s, 2 H) 3.87 (t, J=13.39 Hz, 2 H) 4.74 (quin, J=8.27 Hz, 1 H) 6.81 (d, J=8.34 Hz, 1 H) 7.00 (br. s., 1 H) 7.26 (s, 1 H) 7.50 (br. s., 1 H) 7.58 (s, 1 H) 7.97 (s, 1 H). [M+H] calc'd for C21H22F2N6O2, 429; found 429.

Provenance & Evidence