5-Aminoindole → HCID 25253372, compound

Participants

Role	Name	HCID	Charge
Reactant	5-Aminoindole	HCID 78867	—
Reactant	2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[4,5-B][1,4]diazepin-6(7H)-one	HCID 57955574	—
Product	HCID 25253372	HCID 25253372	—

Reaction Steps

The title compound was prepared using Buchwald reaction from 2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one and 5-aminoindole. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (m, 4 H) 1.69 (m, 2 H) 1.97 (m, 2 H) 3.3 (s, 3 H) 3.99 (t, J=14.3 Hz, 2 H) 4.75 (t, J=8.0 Hz, 1 H) 6.29 (br. s., 1 H) 7.18-7.41 (m, 3 H) 7.96 (s, 1 H) 8.18 (s, 1 H) 9.16 (s, 1 H) 10.91 (br. s., 1 H). [M+H] calc'd for C21H22F2N6O, 413; found 413.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08318727B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-5c1a11c4b2044131ad3d97f267700d7f
Source note	uspto-grants-2012_11