1-(3-Aminopropyl)-2-pyrrolidinone → 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-methoxy-benzamide

Participants

Reaction Steps

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-(3-aminopropyl)pyrrolidin-2-one. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1H NMR (400 MHz, DMSO-d6) δ ppm 1.00 (t, J=7.07 Hz, 3 H) 1.17 (m, 2 H) 1.35-1.80 (m, 12 H) 2.32 (q, J=7.07 Hz, 2 H) 2.87 (br. d., 2 H) 3.33 (s, 3 H) 3.76 (m, 1 H) 3.94 (s, 3 H) 4.06 (t, J=13.64 Hz, 2 H) 4.46 (m, 1 H) 7.47 (d, J=8.59 Hz, 1 H) 7.50 (s, 1 H) 8.14 (d, 1 H) 8.21 (s, 1 H) 8.26 (d, J=8.34 Hz, 1 H). [M+H] calculated for C29H39F2N7O3, 572; found 572.

Provenance & Evidence