HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylhydrazine → HCID 25254460, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylhydrazine | HCID 5976 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoic acid | HCID 25253680 | — |
| Product | HCID 25254460 | HCID 25254460 | — |
Reaction Steps
The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and N,N-dimethyl-hydrazine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15-1.43 (m, 2 H) 1.53-1.92 (m, 8 H) 2.92 (s, 6 H) 3.32 (s, 3 H) 3.96 (s, 3 H) 4.14 (t, J=13.0 Hz, 2 H) 4.42-4.52 (m, 1 H) 7.44-7.52 (m, 2 H) 8.20-8.27 (m, 2 H) 8.49 (br. s., 1 H). [M+H] calc'd for C24H31F2N7O3 504; found 504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318727B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-63bdff0aa051494d8934b47549a6b0ef |
| Source note | uspto-grants-2012_11 |