Cyclopropylamine → HCID 25254939, compound

Participants

Reaction Steps

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and cyclopropylamine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.50-0.61 (m, 2 H) 0.70 (dd, J=7.07, 2.27 Hz, 2 H) 1.31-1.48 (m, 2 H) 1.51-1.70 (m, 4 H) 1.71-1.91 (m, 4 H) 2.81 (dt, J=7.14, 3.63 Hz, 1 H) 3.17 (s, 3 H) 3.93 (s, 3 H) 4.03 (q, J=7.07 Hz, 2 H) 4.46 (t, J=11.62 Hz, 1 H) 7.40-7.55 (m, 2 H) 7.90 (s, 1 H) 8.21 (s, 1 H) 8.26 (d, J=8.34 Hz, 1 H) 8.37 (d, J=3.79 Hz, 1 H). [M+H] C25H30F2N6O3 calc'd for, 501; found 501.

Provenance & Evidence