HCID 57955593, compound → HCID 25254940, compound

Participants

Reaction Steps

Benzyl 4-(4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxybenzamido)piperazine-1-carboxylate (850 mg, 1.25 mmols) was dissolved in ethanol (15 mL), added 10% Pd—C (170 mg, 20% wt) under inert atmosphere and hydrogenated using a balloon for 8 hrs. Then filtered the solution through celite bed and evaporated to give the product (630 mg). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.12-1.89 (m, 10 H) 2.70-2.85 (m, 8 H) 3.31 (s, 3 H) 3.93 (s, 3 H) 4.06 (t, J=13.26 Hz, 2 H) 4.46 (m, 1 H) 7.42 (d, J=8.0 Hz, 1 H) 7.44 (s, 1 H) 7.90 (s, 1 H) 8.21 (s, 1 H) 8.26 (d, J=8.08 Hz, 1 H) 9.38 (s, 1 H). [M+H] calculated for C26H34F2N8O3, 545; found 545.

Provenance & Evidence