N,N-Dimethylglycine → HCID 25255103, compound

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Reaction Steps

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(piperazin-1-yl)benzamide using a procedure that is analogous to that described in connection with amide formation except that N,N-dimethylglycine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.12-1.89 (m, 10 H) 2.19 (s, 6 H) 2.89 (br. s., 2 H) 2.94 (br. s., 2 H) 3.31 (s, 3 H) 3.54 (br. s., 2 H) 3.63 (br. s., 2 H) 3.93 (s, 3 H) 4.06 (t, J=13.39 Hz, 2 H) 4.46 (m, 1 H) 7.42 (d, J=8.0 Hz, 1 H) 7.44 (s, 1 H) 7.91 (s, 1 H) 8.21 (s, 1 H) 8.28 (d, J=8.33 Hz, 1 H) 9.52 (s, 1 H). [M+H] calculated for C30H41F2N9O4, 630; found 630.

Provenance & Evidence