反应详情

温度

80 °C

A mixture of methyl 2-methylglycidate (3.18 g, 27 mmol) and cyclopentylamine (4 mL, 41 mmol) in ethanol (50 mL) was heated at 80° C. for 3 d. The reaction mixture was then concentrated, diluted to EtOAc, washed by NaHCO3, brine and water. Organic layer was dried, concentrated to give a residue which is used for next step without further purification (3.9 g, 60%). [M+H] calc'd for C11H21NO3, 216; found 216.

1. concentrationThe reaction mixture was then concentrated
2. additiondiluted to EtOAc
3. washwashed by NaHCO3, brine and water
4. customOrganic layer was dried
5. concentrationconcentrated
6. customto give a residue which
7. customis used for next step without further purification (3.9 g, 60%)