Ethanol → Ethyl 3-(cyclohexylamino)-2-hydroxy-2-methylpropanoate

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-methylglycidate (3.2 mL, 30 mmol) and cyclohexylamine (5.2 mL, 45 mmol) in ethanol (50 mL) was heated at 80° C. for 24 h. The reaction mixture was then concentrated, diluted to EtOAc, washed by NaHCO3, brine and water. Organic layer was dried, concentrated to give a residue which is used for next step without further purification (6.7 g, 97%). [M+H] calc'd for C12H23NO3, 230; found 230.

Provenance & Evidence