2486-69-3 → HCID 25253068, compound

Participants

Reaction Steps

2-Chloro-9-cyclopentyl-7-fluoro-5-methyl-7-vinyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one, 4-amino-3-methoxy benzoic acid (1.2 equivalent), i-PrOH and conc. HCl (30 drops) were heated to 95° C. for 18 hours. A this time the reaction was cooled to room temperature and filtered to reveal the product as a tan solid in good yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.51-1.75 (m, 6 H) 1.85 (m, 2 H) 3.29 (s, 3 H) 3.73-3.97 (m, 2 H) 3.93 (s, 3 H) 4.94 (m, 1 H) 5.40-5.54 (m, 2 H) 6.05 (m, 1 H) 7.48-7.65 (m, 2 H) 8.09 (d, J=8.34 Hz, 1 H) 8.23 (s, 1 H) 9.51 (br. s., 1 H). [M+H] calculated for C23H26FN5O4, 456; found 456.

Provenance & Evidence